I remember I started watching this drama (the first time) because of Mizushima Hiro, after I had seen him in the movie "Drop" I was attracted to his unique acting skills and personality; much like Satoshi Ohno, it seems as if Mizushima Hiro disappears in to the character he is playing. Although, as soon as I started watching, I became completely distracted by Kimura Takuya. The way he played Tsukumo Ryusuke was amazing! All the quirks, mannerisms, attitudes, behaviors, and personalities he brought to the character himself was fantastic to watch. I absolutely loved the way he laughed out loud, talked about brain science, and how he interacted with the other characters/actors. It was also great to see all the guest actors for each episode! Gackt, Sato Takeru, Kamenashi Kazuya, Sugimoto Tetta, Abe Ryohei, Kimura Tae.... And so much more!! I wish a lot more dramas did this. I also wish Mr. Brain had lots more episodes, a second season, a movie, a special episode... it was way too great of a drama to just end at 8 episodes. Also, since I'm writing this review after I re-watched this drama, I now know who a few of the actors are (Kagawa Teruyuki, Shiho, Shitara Osamu, Ichikawa Ebizo) so it was great to watch them! I would definitely recommend this to someone who is just starting out with foreign/Japanese dramas; or someone who likes to laugh or who likes detective dramas!