I have pretty much expected the "twist" (having watched the first two eps and then some reviews), and still enjoyed it immensly - the experience has probably been even better thanks to it. There are some things we are scared to tell our family/friends about, be it our sexuality, gender or other stuff. It's scary and it ain't easy, but it can be so much better once it's out there than what we have right now. I have treated this story as a story of a trans person, ignoring the whole medical explanation they gave in the show. It made me feel hopeful about the future.